Patents

Automated Detection of Breast Cancer Lesions in Tissue
R. Bhargava, F.N. Pounder, R.K. Reddy
U.S. Patent Application No. 13/222,623
Filed on August 31, 2011.

Apparatus for controlling the propagation and transmission of light in flexible waveguides
G.J. Tearney, R.K. Reddy
Filed in April 2014.

Optical imaging device powered by light
G.J. Tearney, R.K. Reddy
Filed in April 2015.

Actively controlled optical imaging device
G.J. Tearney, R.K. Reddy, M.J. Gora, K.K. Chu, M. Beatty
Filed in September 2015.

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Peer Reviewed Papers

Accurate histopathology from low signal-to-noise ratio spectroscopic imaging data
R.K. Reddy, R. Bhargava
Analyst, 135 , 2818-2825, 2010
[Paper]

Characterization of Tumor Progression in Engineered Tissue using Infrared Spectroscopic Imaging
R. Kong, R.K. Reddy, R. Bhargava
Analyst, 135(7), 1569-1578, 2010
We made the cover of Analyst!
[Paper]

Dark Field Raman Microscopy
M.V. Schulmerich, R.K. Reddy, A.K. Kodali, L.J. Elgass, K. Tangella and R. Bhargava,
Anal. Chem., 82(14), 6273-6280, 2010
[Paper]

Label-free Biomedical Imaging with Mid- Infrared Spectroscopy
M.J. Walsh, R.K. Reddy, R. Bhargava,
IEEE Journal of Selected Topics in Quantum Electronics focusing on Biophotonics 2, 18(4), 1502-1513, 2012
[Paper]

Analysis of Variance components in Spectroscopic Imaging data of Tissue Microarray
J.T. Kwak, R.K. Reddy, S. Sinha, R. Bhargava
Anal. Chem., 84(12), 1063-1069, 2012
[Paper]

Discrete frequency infrared microspectroscopy and imaging with a tunable quantum cascade laser
M.R. Kole, R.K. Reddy, M.V. Schulmerich, M.K. Gelber, R. Bhargava
Anal. Chem., 84(23), 10366-10372, 2012
[Paper]

High-definition Infrared Spectroscopic Imaging
R.K. Reddy, M.J. Walsh, M.V. Schulmerich, P. S. Carney, R. Bhargava
Appl. Spectrosc., 67(1), 93-105, 2013
William F. Meggers award winning paper!
[Paper]

Compositional prior information in computed infrared spectroscopic imaging
B.Deutsch, R.K. Reddy, D. Mayerich, R. Bhargava, P. S. Carney
Journal of the Optical Society of America A, 32(6) 1126 - 1131, 2015
[Paper]

Development of a practical spatial-spectral analysis protocol for breast histopathology using Fourier transform infrared spectroscopic imaging
F.N. Pounder, R.K. Reddy, R. Bhargava
Faraday discussions , 187, 43-68, 2016
[Paper]

uOCT imaging using depth of focus extension by self-imaging wavefront division in a common-path fiber optic probe
Biwei Yin, Kengyeh K. Chu, Chia-Pin Liang, Kanwarpal Singh, R.K. Reddy, and Guillermo J. Tearney
Optics express, 24(5), 5555-5564, 2016
[Paper]

Optimizing the Design of FT-IR Spectroscopic Imaging Instruments to Obtain Increased Spatial Resolution of Chemical Species
R. Reddy, D. Mayerich, M. Walsh, M. Schulmerich, P. S. Carney, R. Bhargava,
International Symposium of Biomedical Imaging (ISBI), Barcelona, Spain, 2012
[Paper]

Rigorous Electromagnetic Model of Fourier Transform Infrared (FT-IR) Spectroscopic Imaging Applied to Automated Histology of Prostate Tissue Specimens
R. Reddy, D. Mayerich, M. Walsh, P. S. Carney, R. Bhargava
International Conference on Optics, Lasers and Spectroscopy (ICOLS), Madrid, Spain, 2012.
[Paper]

Modeling Fourier Transform Infrared Spectroscopic Imaging of Prostate and Breast Cancer Tissue Specimens
R.K. Reddy, B. Davis, P.S. Carney, R. Bhargava
International Symposium of Biomedical Imaging (ISBI), Chicago IL, 2011
[Paper]

Towards Better than Human Capability in Diagnosing Prostate Cancer Using Infrared Spectroscopic Imaging Award winning paper!
X. Llora, R. Reddy, B. Matesic, R. Bhargava
Genetic and Evolutionary Computation Conference (GECCO), London UK, 2007
[Paper]


Book Chapters

Chemometric methods for biomedical Raman spectroscopy and imaging
R.K. Reddy and R. Bhargava
Book: Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields
by M.D. Morris, P.Matousek, Springer-Verlag, Berlin Heidelberg, 2010
[Book]

Fourier transform infrared spectroscopic imaging: An emerging label-free approach for molecular imaging
K. Yeh, R.K. Reddy and R. Bhargava
Book: Emerging Imaging Technologies in Medicine
by M. Anastasio, P.J. La Riviere, Taylor & Francis, Philadelphia, USA, 2012
[Book]


Ph.D. Thesis

Mid-Infrared Spectroscopic Imaging and Tomography
R.K. Reddy
Advisor: Dr.Rohit Bhargava
University of Illinois at Urbana Champaign, 2013.


Invited Talks

Design of high resolution FT-IR spectroscopic imaging instruments for improved breast cancer detection
R.K. Reddy, D. Mayerich, M.J. Walsh, P.S.Carney, R.Bhargava
SPIE Photonics West, San Fransisco, CA, Feb. 10th, 2015

Building mid-infrared spectroscopic imaging instruments for improved breast cancer detection
R.K. Reddy
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Feb. 3rd, 2015

High Resolution FT-IR Imaging for Improvd Breast Cancer Detection
R.K. Reddy, D. Mayerich, M.J. Walsh, P.S.Carney, R.Bhargava
Science Exchange (SciX) conference organized by Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), Reno, NV, Oct. 1st, 2014

Seeing the unseen in human tissue
R.K. Reddy, K.K. Chu, T.N.Ford, K. Singh, R.W. Carruth, D. Hyun, H. Ma, D. Mojahed, C. Unglert, G.J. Tearney,
Science Exchange (SciX) conference organized by Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), Reno, NV, Oct. 1st, 2014

Mid-infrared Spectroscopic Imaging and Tomography
R.K. Reddy, P.S.Carney, R.Bhargava
Massachusetts General Hospital, Harvard Medical School, July 9th, 2013

Instrumentation for Infrared Spectroscopic Imaging
R.K. Reddy, R.Bhargava
Lam Research, Fremont, California, October 23rd, 2012

Vibrational Spectroscopy
R.K. Reddy, Thomas van Dijk, R.Bhargava
Roger Adams Laboratory, University of Illinois at Urbana Champaign, Jan 31st, 2012

Fourier Transform Infrared (FT-IR) Spectroscopic Imaging of Human Tissue Specimens
R.K. Reddy, D. Mayerich, M.J. Walsh, M.V. Schulmerich, P.S.Carney, R.Bhargava
Beckman Graduate Seminar, Beckman Institute for Advanced Science and Technology, Urbana IL, Nov 2, 2010

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Conference Presentations

Tethered Capsule Endomicroscopy for Barretts Esophagus Screening
R.K. Reddy, M.J. Gora, R. Carruth, T.N. Ford, J. Dong, G.J. Tearney,
Science Exchange (SciX) conference organized by Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), Providence, RI, Oct. 1st, 2015

Functional micron-resolution imaging with micro-optical coherence tomography
R.K. Reddy, K.K. Chu, T.N.Ford, K. Singh, R.W. Carruth, D. Hyun, H. Ma, D. Mojahed, C. Unglert, G.J. Tearney
Science Exchange (SciX) conference organized by Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) , Reno, NV, Oct. 2nd, 2014

Improved Breast Cancer Detetion from High-Resolution Fourier Transform Infrared (FTIR) Spectroscopic Imaging
R.K. Reddy, D. Mayerich, M.J. Walsh, M.V. Schulmerich, R. Bhargava
Science Exchange (SciX) conference organized by Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) , Milwakee, WI, Oct. 3rd, 2013

Classification of Prostate and Breast Tissue Data from High-Resolution Fourier Transform Infrared (FTIR) Spectroscopic Imaging
R.K. Reddy, D. Mayerich, M.J. Walsh, M.V. Schulmerich, R. Bhargava,
Science Exchange (SciX) conference organized by Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) , Kansas City, MO, Oct. 1st, 2012

High resolution FT-IR spectroscopic imaging instruments for cancer detection
R.K. Reddy, M.J. Walsh, M. Schulmerich, P.S. Carney, R. Bhargava
(Poster) Univ. of Illinois at Urbana Champaign Community at Illinois Symposium, Chicago, April 5th, 2012

Rigorous Electromagnetic Model of Fourier Transform Infrared (FT-IR) Spectroscopic Imaging Applied to Automated Histology of Prostate Tissue Specimens
R.K. Reddy, D. Mayerich, M. Walsh, P. S. Carney, R. Bhargava
International Conference on Optics, Lasers and Spectroscopy (ICOLS), Madrid, Spain, March 28th, 2012

Design of high resolution FT-IR spectroscopic imaging instruments for cancer detection
R.K. Reddy, M.J. Walsh, M. Schulmerich, P.S. Carney, R. Bhargava
(Poster) Univ. of Illinois at Chicago Cancer Center Research Forum, Chicago, March 6th, 2012

High Definition Fourier Transform Infrared (FT-IR) Spectroscopic Imaging
R. Reddy, D. Mayerich, M. Walsh, M. Schulmerich, P.S. Carney, R. Bhargava
Midwest ACS meeting, Oct. 19th, 2011

Overcoming Spectral Distortions in Fourier Transform Infrared (FT-IR) Spectroscopic Imaging
R.K. Reddy, P.S. Carney, R. Bhargava,
Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) , Reno, NV, Oct. 2nd, 2011

Theory of resolution and image quality in mid-IR imaging
R. Bhargava, T. van Dijk, R.K. Reddy, P.S. Carney
Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) 2011, Reno, October 3rd, 2011.

High-Definition FT-IR Spectroscopic Imaging
R.K. Reddy, R. Bhargava
Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) , Reno, NV, Oct. 4th, 2011

High Definition Fourier Transform Infrared (FT-IR) Spectroscopic Imaging (Award Winning Poster!)
R.K. Reddy, M.J. Walsh, M. Schulmerich, P.S. Carney, R. Bhargava
(Poster) Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) 2011, Reno, NV, Oct. 4th, 2011

Fourier-Transform Infrared Spectroscopic Imaging for Histopathology
R.K. Reddy, R.Bhargava
(Poster) BioSensing and BioActuation Summer Institute 2011, National Taiwan University, Taiwan, July 22nd, 2011

Modeling Fourier transform infrared spectroscopic imaging of Prostate and breast cancer tissue specimens
R.K. Reddy, B.J. Davis, P.S. Carney, R. Bhargava
IEEE International Symposium on Biomedical Imaging (ISBI), Chicago, March 30th, 2011

Enhanced Models for Fourier Transform Infrared (FT-IR) Spectroscopic Imaging of Human Tissue Specimens (Award Winning Poster!)
R.K. Reddy, B.J. Davis, P.S. Carney, R. Bhargava
Federation of Analytical Chemistry and Spectroscopy Societies FACSS ), Rayleigh, NC, Oct. 4th, 2010

Modeling, Data Visualization and Histopathology using Fourier Transform Infrared (FT-IR)  Spectroscopic Imaging of Human Tissue Specimens (Award Winning Poster!)
R.K. Reddy, F.N. Pounder, R. Bhargava
(Poster), Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), Louisville, KY, Oct. 19th, 2009

Modeling, Data Visualization and Histopathology using Fourier Transform Infrared (FT-IR) Spectroscopic Imaging of Human Tissue Specimens
R.K. Reddy, R. Bhargava
Biomedical Engineering Society Conference (BMES), Pittsburgh, PA, Oct. 8th, 2009

Fourier-Transform Infrared Spectroscopic Imaging
R.K. Reddy, R.Bhargava
(Poster) NanoBiophotonics Summer School 2009, Urbana IL, June 4th, 2009

Advances in Automated Histopathology using Fourier Transform Infrared (FT-IR) Spectroscopic Imaging
R.K. Reddy, R. Bhargava
(Poster) Univ. of Michigan at Ann Arbor, Midwestern Biomedical Engineering Conference, April 3rd, 2009

Robustness of Tissue Classification using FT-IR Imaging
R.K. Reddy, R. Bhargava
Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) , Reno, NV, Sept. 30th, 2008

Enhancing the tissue segmentation capability of fast infrared spectroscopic imaging via chemometric methods,
R. Bhargava, F.N. Pounder, R.K. Reddy, X. Llora
Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) , Reno, NV, Sept. 30th, 2008

Advances in Automated Histopathology using Fourier Transform Infrared (FT-IR) Spectroscopic Imaging
R.K. Reddy, R. Bhargava
(Poster) Biomedical Engineering Society Conference (BMES), St.Louis, MO, Oct 3rd, 2008

Computational Methods for Enhancing Infrared Spectroscopic Imaging (Award Winning Poster!)
R. Reddy, R.Bhargava
Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) , Memphis TN, Oct 14th, 2007


Masters Thesis

3D Warped Discrete Cosine Transform and its application in Image Compression
R.Reddy, K.M.M.Prabhu
Indian Institute of Technology Madras, Chennai, India, July 2006.


Other Publications

Denoising and deblurring of Fourier-trasform infrared spectroscopic imaging
T.H. Nguyen, R.K. Reddy, M. J. Walsh, M. Schulmerich, G. Popescu, M.N. Do, R. Bhargava
Society of Photo-Optical Instrumentation Engineers (SPIE) Photonics West, Paper No. 8296-20, 2012

Re-imagining FT-IR imaging and applications with new theory and instruments
R. Bhargava, P.S. Carney, R.K. Reddy
SciX, Kansas City, October 2012

Development of highly sensitive and specific vibrational spectroscopic imaging guided by new theory
R. Bhargava, A.K. Kodali, X. Llora, R.K. Reddy, M.J. Walsh, P.S. Carney
EAS 2011, Somerset, NJ, November 2011

Validating the cancer diagnosis potential of mid-infrared spectroscopic imaging
F.N. Pounder, R.K. Reddy, M. Walsh and R. Bhargava
Society of Photo-Optical Instrumentation Engineers (SPIE 2009) Photonics West, Paper No. 7186-14, 2009

Practical protocols for ultrafast histopathology by Fourier transform infrared imaging
F.N. Keith, R.K. Reddy, and R. Bhargava
Society of Photo-Optical Instrumentation Engineers (SPIE) Photonics West, Paper No. 6853A-5, 2008

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